A river-threaded skyline, brass-toned jazz echoes, and the towering Gateway Arch give St. Louis a magnetic blend of history and modern energy. We list the best hotels in St. Louis based on expert recommendations and thousands of guest reviews. All of our recommended hotels have a review rating of at least 4 out of 5 stars.
Best cheap hotel: Aloft St. Louis Cortex
Best boutique hotel: 21c Museum Hotel St Louis
Best luxury hotel: Four Seasons St. Louis
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The Moonrise Hotel sits in St. Louis’s Loop, the city’s nightlife and dining hub, making its rooftop bar feel right at home. Inside, a space-themed design blends with curvy mid-century modernism, turning modern style into something playful rather than pretentious. Suites honor famous local figures, while rooms include essentials like plasma TVs and sleek bathrooms.
Fun defines the Moonrise and sets it apart from coastal boutique hotels. The atmosphere feels inclusive rather than exclusive, inviting curiosity instead of intimidation, even revolving moon replica spinning on roof.
21c Museum Hotels combine contemporary art collections with luxury boutique hospitality in unexpected cities rather than major hubs. Their tenth location is in St. Louis, Missouri, where they transformed a century-old Renaissance Revival YMCA into a 173-room hotel and museum.
Rooms and suites reflect 21c’s modernist aesthetic, appealing to design enthusiasts and traditional guests alike. Each unit includes original artwork and upscale amenities such as 50-inch televisions and Malin+Goetz bath products.
The Four Seasons Hotel St. Louis rises with striking views of the Gateway Arch, especially from its 19-story height. Even before stepping inside, the sleek exterior and arrival experience set a refined tone, as guests approach an entrance designed to impress.
Inside, glass doors open to attentive staff ready to assist, while the sound of flowing water from a central feature fills the space. A sculpted artwork sits at the heart of the lobby, creating a calm, sensory-rich atmosphere that invites guests into a thoughtfully crafted world of elegance and detail.
The Ritz-Carlton, St. Louis is set in upscale Clayton, offering a blend of Midwestern hospitality with easy access to arts, gardens, dining, Forest Park, museums, and boutiques. Guest rooms are spacious, many with balconies overlooking downtown Clayton and the park, and the property includes a fitness center with panoramic views plus a luxury spa with massages, facials, and a sauna.
Dining includes the Lobby Lounge for cocktails and light bites, along with Casa Don Alfonso, which serves Mediterranean cuisine inspired by the Sorrento coast.
Aloft St. Louis Cortex is a sleek, modern stay tucked into St. Louis’s innovation district, the Cortex. It feels more like a buzzing urban loft than a traditional hotel, surrounded by startups, labs, and university energy. The vibe is youthful, with bold design and open spaces that invite both work and unwinding.
Inside, you’ll find comfy rooms with minimalist flair, a lively bar scene, and social lounges that hum into the evening. It’s a solid pick for business travelers or curious wanderers who like being plugged into the city’s tech-forward pulse.